Journal profile · Physiology
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
ISSN 0363-6119 · eISSN 1522-1490 · American Physiological Society · UNITED STATES · Monthly · Founded 1977
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology: CAS Zone 4 · Medicine (2025 upgraded edition); hybrid open access; median 111 days to acceptance (95 articles, last 24 months); community-reported acceptance: about 25%; 173 articles in 2025; indexed in SCIE and Scopus.
Scope
Aims, scope and focus
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology is published by American Physiological Society and is in Zone 4 of Medicine in the CAS Journal Ranking (2025 upgraded edition). By OpenAlex counts of its recent articles, its largest topics are Regulation of Appetite and Obesity, Heart Rate Variability and Autonomic Control and Neuroscience of respiration and sleep, together about 25.1% of its articles. Its main subfields are Cardiology and Cardiovascular Medicine. (generated from OpenAlex topic counts and CAS ranking data)
The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.
Source: LetPub
Research area (LetPub): Physiology
Main research topics OpenAlex counts of recent articles; shares are approximate
- Regulation of Appetite and ObesityNeuroscience9%
- Heart Rate Variability and Autonomic ControlMedicine8.9%
- Neuroscience of respiration and sleepNeuroscience7.1%
- Renin-Angiotensin System StudiesMedicine7%
- Cardiovascular and exercise physiologyMedicine5.9%
- Physiological and biochemical adaptationsEnvironmental Science5.8%
- Neuropeptides and Animal PhysiologyNeuroscience5.8%
- Ion Transport and Channel RegulationBiochemistry, Genetics and Molecular Biology4.8%
Rankings & indexing
CAS ranking and database indexing
CAS Journal Ranking
CAS Journal Ranking, upgraded edition (March 2025)Medicine Zone 4
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 4 |
| Minor | Physiology | Zone 3 |
Top journal: noReview journal: no
CAS Xinrui Journal Ranking (March 2026)Medicine Zone 3
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 3 |
| Minor | Physiology | Zone 3 |
Top journal: noReview journal: not marked
CAS Journal Ranking, previous upgraded edition (December 2023)Medicine Zone 3
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 3 |
| Minor | Physiology | Zone 3 |
Top journal: noReview journal: no
CiteScore quartiles (Scopus, June 2026 release)
| Subject | Quartile | Rank | Percentile |
|---|---|---|---|
| Physiology (medical) | Q2 | 52/117 | 55th |
| Physiology | Q2 | 91/196 | 53rd |
Scopus ranks journals by CiteScore within each subject: the 75th percentile and above is Q1, then a quartile every 25 points. A different system from the CAS zones.LetPub
Database indexing
SCIEScopusLetPub
International journal early-warning lists: not listed in any editionLetPub
Editions, and major and minor categories, are shown separately and never merged into one zone; check which edition your institution uses before you submit or report.
Metrics
Impact metrics and publication volume
Impact
- CiteScore 2026-06
- 4.5LetPub ·
- SJR 2026-06
- 0.9LetPub ·
- SNIP 2026-06
- 1.08LetPub ·
- h-index
- 160LetPub ·
- h-index
- 246OpenAlex ·
- i10-index
- 12,678OpenAlex ·
- 2-year mean citedness
- 2.28OpenAlex ·
- Self-citation rate
- 3.8%LetPub ·
- Share of gold OA articles
- 35.16%LetPub ·
Volume
- Articles per year
- 147LetPub ·
Articles by year OpenAlex count · 15,526 in total · the current year is incomplete
| Year | Articles | Open access | Citations |
|---|---|---|---|
| 2026 | 141 | 125 | 12,638 |
| 2025 | 173 | 171 | 19,016 |
| 2024 | 110 | 75 | 20,871 |
| 2023 | 131 | 71 | 22,248 |
| 2022 | 157 | 99 | 24,486 |
| 2021 | 165 | 113 | 28,004 |
Sources count differently and were observed at different times, so each source's own value is kept; "publisher" marks figures from the journal's website.
Review & acceptance
Review time and acceptance
Review time from article dates manuscript dates registered with Crossref · to
111 daysMedian, submission to acceptance · P25–P75 83 days – 167 days
- Acceptance to online
- median 30 days (95 articles)
- Submission to online
- median 152 days
- Sample
- 95 articles with submission and acceptance dates (337 in the window); the latest was accepted on
Only articles that were accepted and published are counted, not the time spent on rejected manuscripts, so this usually runs longer than a publisher's "time to first decision".
Other sources
- Average review time (community reports)
- about 2 monthsLetPub ·
- Average acceptance (community reports)
- 25%LetPub ·
Community reports come from authors' own submissions (confidence 0.5) and are not a promise from the journal; for publisher figures, the journal's own definitions apply.
Fees & open access
APC and open-access policy
Hybrid open accessLetPub
A subscription journal in which authors can pay to publish their article open access.
No source has fee information yet; check the journal's website.
A hybrid journal charges the APC only when the author chooses open access; publishing under the subscription model is usually free.
The journal's website is authoritative for fees; sources were observed at different times and each keeps its own value, without averaging.
Profile
Publication details and official links
- Publisher
- American Physiological Society
- Country or region
- UNITED STATES
- Language
- English
- Frequency
- Monthly
- Founded
- 1977
- ISSN
- 0363-6119
- Electronic ISSN
- 1522-1490
- Official links
- Journal homepage ↗LetPub
- Submission system ↗LetPub
FAQ
Frequently asked questions about American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
What CAS zone is American Journal of Physiology-Regulatory, Integrative and Comparative Physiology in?
In the 2025 upgraded edition of the CAS Journal Ranking, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology is in Zone 4 of Medicine, and in Zone 3 of the minor category Physiology. In the 2026 Xinrui edition it is in Zone 3 of Medicine. Zones from different editions, and from major and minor categories, are not interchangeable.
How long does peer review take at American Journal of Physiology-Regulatory, Integrative and Comparative Physiology?
Based on the dates recorded on 95 articles published between October 2024 and October 2026 (the last 24 months), the median time from submission to acceptance is 111 days (interquartile range 83–167 days); authors report an average review time of about 2 months; the community-reported acceptance is “about 25%”. Article statistics cover accepted papers only, publisher figures follow the journal's own definitions, and community reports come from authors' own submissions; none is a promise from the journal.
Which databases index American Journal of Physiology-Regulatory, Integrative and Comparative Physiology?
According to LetPub and DOAJ records, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology is indexed in SCIE and Scopus.
Is American Journal of Physiology-Regulatory, Integrative and Comparative Physiology open access, and what is the APC?
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology is a hybrid journal. Fee information is not available yet; check the journal's website.
Sources and updates
The facts on this page come from LetPub, OpenAlex; every figure is tagged with its source and the date it was observed, and conflicting values are kept per source. LetPub source page: view ↗ (archived 2026-08-26). Last updated: .