Journal profile · Toxicology
Toxicology in Vitro
ISSN 0887-2333 · eISSN 1879-3177 · Elsevier Ltd · ENGLAND · Bimonthly · Founded 1987
Toxicology in Vitro: CAS Zone 4 · Medicine (2025 upgraded edition); impact factor 2.73; hybrid open access; APC about USD 4,200; median 110 days to acceptance (100 articles, last 24 months); community-reported acceptance: about 50%; 135 articles in 2025; indexed in SCIE and Scopus.
Scope
Aims, scope and focus
Toxicology in Vitro is published by Elsevier Ltd and is in Zone 4 of Medicine in the CAS Journal Ranking (2025 upgraded edition). By OpenAlex counts of its recent articles, its largest topics are Animal testing and alternatives, Carcinogens and Genotoxicity Assessment and Effects and risks of endocrine disrupting chemicals, together about 26.1% of its articles. (generated from OpenAlex topic counts and CAS ranking data)
Affiliated with the American Association for Cellular and Computational Toxicology and the European Society for Toxicology in Vitro.Toxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for toxicological evaluations (collectively described as New Approach Methodologies (NAM)). This includes the utilisation or the development of NAMs for assessing the potential adverse effects of chemicals for human safety assessment. In vitro techniques include primary cells, tissue slices, cell lines and stem cells (adult, embryonic and induced Pluripotent cells) or subcellular preparations thereof. Our journal strongly supports the Reduction, Refinement and Replacement (3R) of animals in toxicology evaluations.This is a wide topic and thus we have certain preferences including:Development of in vitro techniques and their application to research and regulatory use (i.e. 3R principle.Mechanistic underpinning of data.Ability to translate outcome to human safety assessment.We strongly encourage :The use of normal (non-transformed) human cells (where appropriate).Reporting the Short Tandem Repeat (STR) profile of the cells used (especially when cells have been provided as a gift or generated in house).Free access to raw (or primary) data.Appropriate model characterisation.The use (or reduction) of animal free components, including serum. [Especially when the system was already developed under such conditions, such as the HK-2 cell line].Attention to detailed methodology and appropriate statistics. [Readers need to know how you did the experiment, how many times, how many replicates etc?]Reporting the source of the compounded tested, catalogue no. and lot no. Where the chemical has been purified or synthesised a full analytical report is expected.Quantification of compounds in exposure medium and/or cells over time (biokinetics).We do not accept solely in vivo investigations and rarely accept animal in vivo, in vitro hybrid papers, except where the animal data was critical in the interpretation or validation of the in vitro data (and not merely confirmatory).We generally discourage investigations relating:Unidentified mixtures - for example in plant extracts.Solely pharmacological investigations (e.g. demonstrating your chemical kills cancer cells in vitro is not generally acceptable).Use of non-human cells when human equivalents exist and are available.The lack of adherence to established protocols, without direct explanation.Reporting cytotoxicity alone, with no mechanistic underpinning and/or no estimation of chemical exposure.
From the journal's Aims & Scope
Research area (LetPub): Toxicology
Editor-in-chief Paul JenningsPublisher website
Editorial board by country: none in mainland China; most named United States 14, Netherlands 8, Germany 6, Spain 3, United Kingdom 2 (42 members with a country) Editorial board ↗Publisher website ·
Main research topics OpenAlex counts of recent articles; shares are approximate
- Animal testing and alternativesVeterinary9.8%
- Carcinogens and Genotoxicity AssessmentBiochemistry, Genetics and Molecular Biology9.2%
- Effects and risks of endocrine disrupting chemicalsEnvironmental Science7.2%
- Pharmacogenetics and Drug MetabolismPharmacology, Toxicology and Pharmaceutics5.2%
- Pesticide Exposure and ToxicityAgricultural and Biological Sciences4.9%
- Drug Transport and Resistance MechanismsMedicine4.3%
- Diverse Scientific and Economic StudiesEconomics, Econometrics and Finance4.2%
- Human auditory perception and evaluationEngineering4.2%
Rankings & indexing
CAS ranking and database indexing
CAS Journal Ranking
CAS Journal Ranking, upgraded edition (March 2025)Medicine Zone 4
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 4 |
| Minor | Toxicology | Zone 4 |
Top journal: noReview journal: no
CAS Xinrui Journal Ranking (March 2026)Medicine Zone 3
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 3 |
| Minor | Toxicology | Zone 3 |
Top journal: noReview journal: not marked
CAS Journal Ranking, previous upgraded edition (December 2023)Medicine Zone 3
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 3 |
| Minor | Toxicology | Zone 3 |
Top journal: noReview journal: no
Database indexing
SCIEScopusLetPub
International journal early-warning lists: not listed in any editionLetPub
Editions, and major and minor categories, are shown separately and never merged into one zone; check which edition your institution uses before you submit or report.
Metrics
Impact metrics and publication volume
Impact
- Impact factor
- 2.73LetPub ·
- Impact factor (publisher)
- 2.7Publisher website ·
- CiteScore 2026-06
- 5.7LetPub ·
- CiteScore (publisher)
- 5.7Publisher website ·
- SJR 2026-06
- 0.71LetPub ·
- SNIP 2026-06
- 0.7LetPub ·
- h-index
- 96LetPub ·
- h-index
- 151OpenAlex ·
- i10-index
- 4,488OpenAlex ·
- 2-year mean citedness
- 3.32OpenAlex ·
- Self-citation rate
- 0%LetPub ·
- Share of gold OA articles
- 24.38%LetPub ·
Volume
- Articles per year
- 121LetPub ·
Articles by year OpenAlex count · 6,836 in total · the current year is incomplete
| Year | Articles | Open access | Citations |
|---|---|---|---|
| 2026 | 81 | 25 | 23 |
| 2025 | 135 | 56 | 354 |
| 2024 | 179 | 59 | 935 |
| 2023 | 170 | 68 | 1,468 |
| 2022 | 187 | 68 | 2,161 |
| 2021 | 173 | 64 | 2,826 |
Sources count differently and were observed at different times, so each source's own value is kept; "publisher" marks figures from the journal's website.
Review & acceptance
Review time and acceptance
Review time from article dates manuscript dates registered with PubMed · to
110 daysMedian, submission to acceptance · P25–P75 83 days – 156 days
- Acceptance to online
- median 2 days (100 articles)
- Submission to online
- median 113 days
- Sample
- 100 articles with submission and acceptance dates (261 in the window); the latest was accepted on
Only articles that were accepted and published are counted, not the time spent on rejected manuscripts, so this usually runs longer than a publisher's "time to first decision".
Other sources
- Average review time (community reports)
- about 2 monthsLetPub ·
- Average acceptance (community reports)
- 50%LetPub ·
- Submission to first decision
- 5 daysPublisher website ·
- First decision after review
- 61 daysPublisher website ·
- Submission to acceptance
- 120 daysPublisher website ·
- Acceptance to publication
- 3 daysPublisher website ·
- Peer review
- Single anonymous peer reviewPublisher website
Community reports come from authors' own submissions (confidence 0.5) and are not a promise from the journal; for publisher figures, the journal's own definitions apply.
Fees & open access
APC and open-access policy
Hybrid open accessLetPub
A subscription journal in which authors can pay to publish their article open access.
| Source | APC | Fee waiver | License | Observed |
|---|---|---|---|---|
| OpenAlex | USD 4,200 / EUR 3,930 / GBP 3,360 / JPY 520,930 | — | — | |
| Publisher website | USD 3,940 | — | — |
A hybrid journal charges the APC only when the author chooses open access; publishing under the subscription model is usually free.
The journal's website is authoritative for fees; sources were observed at different times and each keeps its own value, without averaging.
Submission
Article types and submission policies (journal website)
Open calls for papers1, by deadline
Publisher websiteWhat to prepare6 items from the author guidelines
- Abstract
- ≤ 200 words
- Keywords
- ≥ 1
- Reference style
- Author–date
- First submission
- Free format: the journal's layout is not required
- Highlights
- Required
- Graphical abstract
- Optional
Article types accepted10, with length limits
- brief communicationThe Journal's main purpose will be the publication of papers reporting and interpreting original toxicological research involving the application or development…main text ≤ 2,500 words
- brief communicationsBrief Communications (2,500 word limit) documenting important new findings warranting expeditious publication will also be consideredLength not stated
- correspondenceThe Journal's main purpose will be the publication of papers reporting and interpreting original toxicological research involving the application or development…Length not stated
- letterThe Journal's main purpose will be the publication of papers reporting and interpreting original toxicological research involving the application or development…Length not stated
- letters to the editorThe Journal's main purpose will be the publication of papers reporting and interpreting original toxicological research involving the application or development…Length not stated
- original research papersToxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for t…Length not stated
- reviewThe Journal's main purpose will be the publication of papers reporting and interpreting original toxicological research involving the application or development…Length not stated
- reviewsToxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for t…Length not stated
- reviews (interpretative)as will concise interpretative Reviews of toxicological topics of contemporary significanceLength not stated
- workshop reportsToxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for t…Length not stated
Policy excerpts from the journal's websiteAI use, Authorship, Conflicts of interest, Publication ethics, License & copyright, Open access, Peer review, Preprints, Self-archiving
- AI use Declaration of generative AI use
Authors must declare the use of generative AI tools in the manuscript preparation process upon submission of the paper.Generative AI and AI-assisted technologies (“AI tools”) have been rapidly adopted in research and scholarly publishing, offering significant benefits while requiring clear standards for responsible and transparent use.Authors preparing a manuscript for this journal may use AI tool…
Source ↗Publisher website ·- Authorship Group authorship
Abstract limit 200 words Model summary
Group authorship refers to the attribution of an article to a defined and named group of authors whose members have contributed to the work. Examples include research consortia, clinical trial groups, collaborative networks, task forces or working groups, expert panels or consensus groups, and participatory research groups. Group authorship must be declared on the title page at submission. When av…
Source ↗Publisher website ·- Conflicts of interest Declaration of competing interests
All authors must disclose any financial and personal relationships with other people or organizations that could inappropriately influence or bias their work. Examples of potential competing interests include:EmploymentConsultanciesStock ownershipHonorariaPaid expert testimonyPatent applications or registrationsGrants or any other fundingAffiliation with the journal as an Editor or Advisory Board …
Source ↗Publisher website ·- Publication ethics
Publishing ethics policy Model summary
Authors must follow ethical guidelines stated in Elsevier's Publishing Ethics Policy.
Source ↗Publisher website ·- License & copyright License options
Authors will be offered open access user license options which will determine how you, and third parties, can reuse your open access article. We advise that you review these options and any funding body license requirements before selecting a license option.
Source ↗Publisher website ·- Open access Open access
We refer you to our open access information page to learn about open access options for this journal.
Source ↗Publisher website ·- Peer review Peer review
Single anonymized review process Model summary
This journal follows a single anonymized review process. Your submission will initially be assessed by our editors. If your submission is deemed suitable, it will typically be sent to be reviewed by a minimum of two reviewers for an independent expert assessment of the scientific quality. The decision as to whether your article is accepted or rejected for publication will be made by our editors.Re…
Source ↗Publisher website ·- Preprints Preprints
Preprint sharing allowed Model summary
Preprint sharingAuthors may share preprints in line with Elsevier's article sharing policy. Sharing preprints, such as on a preprint server, will not count as prior publication.We advise you to read our policy on multiple, redundant or concurrent publication.
Source ↗Publisher website ·- Self-archiving
Affiliated societies Model summary
Affiliated with the American Association for Cellular and Computational Toxicology and the European Society for Toxicology in Vitro.
Source ↗Publisher website ·
Excerpts are quoted from the journal's website; "model summary" lines are written by Workers AI and checked against the text. The journal's website is authoritative.
Profile
Publication details and official links
- Publisher
- Elsevier Ltd
- Country or region
- ENGLAND
- Language
- English
- Frequency
- Bimonthly
- Founded
- 1987
- ISSN
- 0887-2333
- Electronic ISSN
- 1879-3177
- Official links
- Journal homepage ↗OpenAlex
- Submission system ↗Publisher website
- Special issues ↗Publisher website
FAQ
Frequently asked questions about Toxicology in Vitro
What CAS zone is Toxicology in Vitro in?
In the 2025 upgraded edition of the CAS Journal Ranking, Toxicology in Vitro is in Zone 4 of Medicine, and in Zone 4 of the minor category Toxicology. In the 2026 Xinrui edition it is in Zone 3 of Medicine. Zones from different editions, and from major and minor categories, are not interchangeable.
What is the impact factor of Toxicology in Vitro?
The latest impact factor listed by LetPub is 2.73; CiteScore 5.7, h-index 151.
How long does peer review take at Toxicology in Vitro?
Based on the dates recorded on 100 articles published between October 2024 and October 2026 (the last 24 months), the median time from submission to acceptance is 110 days (interquartile range 83–156 days); authors report an average review time of about 2 months; the community-reported acceptance is “about 50%”. Article statistics cover accepted papers only, publisher figures follow the journal's own definitions, and community reports come from authors' own submissions; none is a promise from the journal.
What are the manuscript requirements of Toxicology in Vitro?
According to the journal's author guidelines: Abstract: ≤ 200 words; Keywords: ≥ 1; Reference style: Author–date; First submission: Free format: the journal's layout is not required; Highlights: Required; Graphical abstract: Optional. A model extracted these from the author guidelines and each was checked against the text; check the latest version on the journal's website before submitting.
Where are the editorial board members of Toxicology in Vitro based?
Of the 42 board members whose country the journal's board page names, none are in mainland China; the countries named most often are United States (14), Netherlands (8) and Germany (6). Counted from the institutions listed on the board page; for reference only.
Which databases index Toxicology in Vitro?
According to LetPub and DOAJ records, Toxicology in Vitro is indexed in SCIE and Scopus.
Is Toxicology in Vitro open access, and what is the APC?
Toxicology in Vitro is a hybrid journal. For open-access publication: APC about USD 4,200.
Sources and updates
The facts on this page come from LetPub, Publisher website, OpenAlex; every figure is tagged with its source and the date it was observed, and conflicting values are kept per source. LetPub source page: view ↗ (archived 2026-08-26). Last updated: .