Journal profile · Medicine, Research & Experimental
Journal of Clinical Investigation
ISSN 0021-9738 · eISSN 1558-8238 · The American Society for Clinical Investigation · UNITED STATES · Monthly · Founded 1924
Journal of Clinical Investigation: CAS Zone 1 · Medicine (2025 upgraded edition, Top journal); impact factor 13.77; fully open access; APC about USD 5,800; median 260 days to acceptance (60 articles, last 24 months); community-reported acceptance: about 22.5%; 739 articles in 2025; indexed in SCIE and Scopus.
Scope
Aims, scope and focus
Journal of Clinical Investigation is published by The American Society for Clinical Investigation and is in Zone 1 of Medicine in the CAS Journal Ranking (2025 upgraded edition, Top journal). By OpenAlex counts of its recent articles, its largest topics are Immune Cell Function and Interaction, T-cell and B-cell Immunology and Pancreatic function and diabetes, together about 22.2% of its articles. Its main subfields are Immunology. (generated from OpenAlex topic counts and CAS ranking data)
The Journal of Clinical Investigation is a premier venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine.
From the journal's Aims & Scope
Research area (LetPub): Medicine, Research & Experimental
Main research topics OpenAlex counts of recent articles; shares are approximate
- Immune Cell Function and InteractionImmunology and Microbiology8.5%
- T-cell and B-cell ImmunologyImmunology and Microbiology7.2%
- Pancreatic function and diabetesMedicine6.6%
- Monoclonal and Polyclonal Antibodies ResearchMedicine5.1%
- Immunotherapy and Immune ResponsesImmunology and Microbiology5.1%
- Cell Adhesion Molecules ResearchMedicine4.8%
- Adipose Tissue and MetabolismMedicine4.7%
- Diet and metabolism studiesMedicine4.6%
Rankings & indexing
CAS ranking and database indexing
CAS Journal Ranking
CAS Journal Ranking, upgraded edition (March 2025)Medicine Zone 1
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 1 |
| Minor | Medicine, Research & Experimental | Zone 1 |
Top journal: yesReview journal: no
CAS Xinrui Journal Ranking (March 2026)Medicine Zone 1
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 1 |
| Minor | Medicine, Research & Experimental | Zone 1 |
Top journal: yesReview journal: not marked
CAS Journal Ranking, previous upgraded edition (December 2023)Medicine Zone 1
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 1 |
| Minor | Medicine, Research & Experimental | Zone 1 |
Top journal: yesReview journal: no
Database indexing
SCIEScopusDOAJLetPub
International journal early-warning lists: not listed in any editionLetPub
Indexing the journal's website claims
Web of ScienceMEDLINEPMCEmbaseCASPublisher website
Other: Google Scholar, ProQuest, Crossref, Sherpa Romeo, ProQuest Biological Science Collection
As the journal's website lists them, not checked against each database; for Web of Science editions the records above apply.
Editions, and major and minor categories, are shown separately and never merged into one zone; check which edition your institution uses before you submit or report.
Metrics
Impact metrics and publication volume
Impact
- Impact factor
- 13.77LetPub ·
- Impact factor (publisher) 2025
- 14.3Publisher website ·
- CiteScore 2026-06
- 17.3LetPub ·
- SJR 2026-06
- 4.81LetPub ·
- SNIP 2026-06
- 2.42LetPub ·
- h-index
- 447LetPub ·
- h-index
- 714OpenAlex ·
- i10-index
- 32,725OpenAlex ·
- 2-year mean citedness
- 10.7OpenAlex ·
- Self-citation rate
- 1.4%LetPub ·
- Share of gold OA articles
- 99.14%LetPub ·
Volume
- Articles per year
- 549LetPub ·
Articles by year OpenAlex count · 37,793 in total · the current year is incomplete
| Year | Articles | Open access | Citations |
|---|---|---|---|
| 2026 | 545 | 545 | 669 |
| 2025 | 739 | 739 | 6,484 |
| 2024 | 636 | 636 | 13,398 |
| 2023 | 557 | 557 | 19,867 |
| 2022 | 533 | 533 | 27,131 |
| 2021 | 595 | 595 | 37,862 |
Sources count differently and were observed at different times, so each source's own value is kept; "publisher" marks figures from the journal's website.
Review & acceptance
Review time and acceptance
Review time from article dates manuscript dates registered with PubMed · to
260 daysMedian, submission to acceptance · P25–P75 196 days – 374 days
- Acceptance to online
- median 9 days (60 articles)
- Submission to online
- median 289 days
- Sample
- 60 articles with submission and acceptance dates (1,438 in the window); the latest was accepted on
Only articles that were accepted and published are counted, not the time spent on rejected manuscripts, so this usually runs longer than a publisher's "time to first decision".
Other sources
- Average review time (community reports)
- about 2 monthsLetPub ·
- Average acceptance (community reports)
- 22.5%LetPub ·
- Submission to publication (journal-reported)
- about 6 weeksDOAJ ·
- Peer review
- Unspecified peer reviewDOAJ
Community reports come from authors' own submissions (confidence 0.5) and are not a promise from the journal; for publisher figures, the journal's own definitions apply.
Fees & open access
APC and open-access policy
Fully open accessDOAJ
Every article is open access; authors usually pay an article processing charge (APC).
| Source | APC | Fee waiver | License | Observed |
|---|---|---|---|---|
| DOAJ | USD 5,800 | Yes | CC BY | |
| OpenAlex | USD 5,200 | — | — | |
| Publisher website | USD 5,800 / USD 5,600 / USD 5,400 / USD 2,500 / USD 2,400 / USD 2,250 | — | — |
Other charges and waivers (author guidelines)
- Submission fee
- 5,800
The journal's website is authoritative for fees; sources were observed at different times and each keeps its own value, without averaging.
Submission
Article types and submission policies (journal website)
Article types accepted6
- clinical research and public healthClinical Research and Public Health manuscripts report findings derived from human participants, ranging from studies with a small number of patients to large-c…Length not stated
- editorial[Top of page] Submissions Dual-Journal Submission Prior publication Review of manuscripts Transfer of reviews from other journals Guaranteed reviews and rewards…Length not stated
- letter to the editorLetter to the Editor manuscripts comment on a recent JCI research article and must be of substantial impact and interest to the general readership.Length not stated
- researchResearch manuscripts provide substantial new mechanistic insights into biology and disease using preclinical models as well as materials and data derived from h…Length not stated
- research letterResearch Letter manuscripts are focused reports of an original preclinical or clinical research finding of exceptional interest to the JCI readership.Length not stated
- review[Top of page] | [Editorial policies and practices] The Science Editors assign manuscripts to appropriate Associate Editors. Papers may be rejected without exter…Length not stated
Policy excerpts from the journal's websiteAuthorship, Conflicts of interest, Data availability, Publication ethics, License & copyright, Open access
- Authorship Authorship agreement
[Top of page] | [Editorial policies and practices] For revised manuscript submissions, all authors listed on the submission site must approve the submission before the revised version can be sent to the Editorial Board for review. Each listed author will receive an electronic notification, at the email addresses provided at the time of submission, requesting approval. Any changes in authorship ord…
Source ↗Publisher website ·- Conflicts of interest Conflicts of interest
[Top of page] | [Editorial policies and practices] Editors Authors Reviewers Misconduct allegations The Journal of Clinical Investigation and American Society for Clinical Investigation (ASCI) are dedicated to upholding the highest standards of integrity and ethical conduct in research, and in its evaluation and related communication. It is important that the Editors, authors, and referees conduct…
Source ↗Publisher website ·- Data availability Data availability
[Top of page] | [Editorial policies and practices] The Methods section must include a paragraph titled “Data availability” detailing how underlying data and supporting analytic code can be accessed by providing, as applicable: a callout to the Supporting Data Values file, which includes values underlying graphed data and reported means presented in both the main text and supplemental material for …
Source ↗Publisher website ·- Publication ethics Misconduct allegations
[Top of page] | [Conflicts of interest] Allegations of scientific misconduct in JCI publications are taken very seriously and carefully reviewed by the Editors. The Journal holds high standards regarding transparency in conflicts of interest for individuals alleging misconduct just as we do for our Editors, Authors, and Reviewers. Individuals alleging misconduct may still opt to remain anonymous, …
Source ↗Publisher website ·- License & copyright Copyright
[Top of page] Effective with the January 4, 2022, issue, authors retain copyright on all articles, which are published with a Creative Commons Attribution License (CC BY 4.0). See Open access for detailed information.
Source ↗Publisher website ·- Open access
Copyright: authors retain copyright, CC BY 4.0 Model summary
Effective with the January 4, 2022, issue, authors retain copyright on all articles, which are published with a Creative Commons Attribution License (CC BY 4.0).
Source ↗Publisher website ·
Excerpts are quoted from the journal's website; "model summary" lines are written by Workers AI and checked against the text. The journal's website is authoritative.
Profile
Publication details and official links
- Publisher
- The American Society for Clinical Investigation
- Country or region
- UNITED STATES
- Language
- English
- Frequency
- Monthly
- Founded
- 1924
- ISSN
- 0021-9738
- Electronic ISSN
- 1558-8238
- Official links
FAQ
Frequently asked questions about Journal of Clinical Investigation
What CAS zone is Journal of Clinical Investigation in?
In the 2025 upgraded edition of the CAS Journal Ranking, Journal of Clinical Investigation is in Zone 1 of Medicine, and in Zone 1 of the minor category Medicine, Research & Experimental; it is a Top journal. In the 2026 Xinrui edition it is in Zone 1 of Medicine. Zones from different editions, and from major and minor categories, are not interchangeable.
What is the impact factor of Journal of Clinical Investigation?
The latest impact factor listed by LetPub is 13.77; CiteScore 17.3, h-index 714.
How long does peer review take at Journal of Clinical Investigation?
Based on the dates recorded on 60 articles published between October 2024 and October 2026 (the last 24 months), the median time from submission to acceptance is 260 days (interquartile range 196–374 days); authors report an average review time of about 2 months; the community-reported acceptance is “about 22.5%”. Article statistics cover accepted papers only, publisher figures follow the journal's own definitions, and community reports come from authors' own submissions; none is a promise from the journal.
Which databases index Journal of Clinical Investigation?
According to LetPub and DOAJ records, Journal of Clinical Investigation is indexed in SCIE, Scopus and DOAJ. The journal's website also lists Web of Science, MEDLINE, PMC, Embase and CAS; that list has not been checked against each database.
Is Journal of Clinical Investigation open access, and what is the APC?
Journal of Clinical Investigation is a fully open-access journal. APC about USD 5,800.
Sources and updates
The facts on this page come from LetPub, OpenAlex, DOAJ, Publisher website; every figure is tagged with its source and the date it was observed, and conflicting values are kept per source. LetPub source page: view ↗ (archived 2026-08-25). Last updated: .