Journal profile · Biochemistry & Molecular Biology

Proteins Structure Function and Bioinformatics

ISSN 0887-3585 · eISSN 1097-0134 · Wiley-Liss Inc. · UNITED STATES · Semimonthly · Founded 1986

Proteins Structure Function and Bioinformatics: CAS Zone 4 · Biology (2025 upgraded edition); impact factor 3.24; hybrid open access; APC about USD 4,550; median 143 days to acceptance (97 articles, last 24 months); community-reported acceptance: fairly easy; 203 articles in 2025; indexed in SCIE and Scopus.

Impact factor3.24Latest value listed by LetPub
CAS zoneZone 4 · Biology2025 upgraded edition, major category · 2026 Xinrui edition Zone 3 · Biology
Review time143 daysMedian, submission to acceptance · 97 articles, last 24 months · Crossref
APCUSD 4,550Hybrid journal: charged only for open-access articles
AcceptanceFairly easyCommunity average
Articles per year2032025 · OpenAlex count

Scope

Aims, scope and focus

Proteins Structure Function and Bioinformatics is published by Wiley-Liss Inc. and is in Zone 4 of Biology in the CAS Journal Ranking (2025 upgraded edition). By OpenAlex counts of its recent articles, its largest topics are Protein Structure and Dynamics, Enzyme Structure and Function and RNA and protein synthesis mechanisms, together about 57% of its articles. Its main subfields are Molecular Biology. (generated from OpenAlex topic counts and CAS ranking data)

PROTEINS : Structure, Function, and Bioinformatics publishes original reports of significant experimental and analytic research in all areas of protein research: structure, function, computation, genetics, and design. The journal encourages reports that present new experimental or computational approaches for interpreting and understanding data from biophysical chemistry, structural studies of proteins and macromolecular assemblies, alterations of protein structure and function engineered through techniques of molecular biology and genetics, functional analyses under physiologic conditions, as well as the interactions of proteins with receptors, nucleic acids, or other specific ligands or substrates. Research in protein and peptide biochemistry directed toward synthesizing or characterizing molecules that simulate aspects of the activity of proteins, or that act as inhibitors of protein function, is also within the scope of PROTEINS. In addition to full-length reports, short communications (usually not more than 4 printed pages) and prediction reports are welcome. Reviews are typically by invitation; authors are encouraged to submit proposed topics for consideration. Proteins is bringing web-based technology to bear to speed and simplify the entire publication process. Proteins now offers online submission and peer review and encourages electronic submission of manuscripts, which expedites the review process. In addition, individual articles are published online as rapidly as possible after acceptance. Please see the Author Instructions for details. Proteins is pleased to announce that online access to the full-text content of all Structure Notes is freely available to all nonsubscribing users , commencing 2003. Structure Notes, first launched in 1999, are one-to-two-page articles describing a novel protein structure of unknown function and/or those with recurring topology. Structure Notes are published within three months of receipt at the Proteins office by expediting all stages of editorial review and production. Please see the Author Instructions for details.

From the journal's Aims & Scope

Research area (LetPub): Biochemistry & Molecular Biology

Editor-in-chief Nikolay V. DokholyanPublisher website

Editorial board by country: 4 in mainland China (about 9%); most named United States 28, Mainland China 4, Germany 3, Canada 3, Israel 2 (44 members with a country) Editorial board ↗Publisher website ·

Main research topics OpenAlex counts of recent articles; shares are approximate

  1. Protein Structure and DynamicsBiochemistry, Genetics and Molecular Biology26.6%
  2. Enzyme Structure and FunctionMaterials Science20.6%
  3. RNA and protein synthesis mechanismsBiochemistry, Genetics and Molecular Biology9.8%
  4. Computational Drug Discovery MethodsComputer Science4.4%
  5. Machine Learning in BioinformaticsBiochemistry, Genetics and Molecular Biology4.2%
  6. Glycosylation and Glycoproteins ResearchBiochemistry, Genetics and Molecular Biology3.4%
  7. Bacterial Genetics and BiotechnologyBiochemistry, Genetics and Molecular Biology2.5%
  8. Monoclonal and Polyclonal Antibodies ResearchMedicine2.4%

Rankings & indexing

CAS ranking and database indexing

CAS Journal Ranking

CAS Journal Ranking, upgraded edition (March 2025)Biology Zone 4
LevelCategoryZone
MajorBiologyZone 4
MinorBiochemistry & Molecular BiologyZone 4
MinorBiophysicsZone 4

Top journal: noReview journal: no

CAS Xinrui Journal Ranking (March 2026)Biology Zone 3
LevelCategoryZone
MajorBiologyZone 3
MinorBiochemistry & Molecular BiologyZone 4
MinorBiophysicsZone 3

Top journal: noReview journal: not marked

CAS Journal Ranking, previous upgraded edition (December 2023)Biology Zone 4
LevelCategoryZone
MajorBiologyZone 4
MinorBiochemistry & Molecular BiologyZone 4
MinorBiophysicsZone 4

Top journal: noReview journal: no

Database indexing

SCIEScopusLetPub

International journal early-warning lists: not listed in any editionLetPub

Indexing the journal's website claims

MEDLINEPubMedINSPECEmbaseCASCAB AbstractsDBLPCurrent ContentsPublisher website

Other: ProQuest

As the journal's website lists them, not checked against each database; for Web of Science editions the records above apply.

Editions, and major and minor categories, are shown separately and never merged into one zone; check which edition your institution uses before you submit or report.

Metrics

Impact metrics and publication volume

Impact

Impact factor
3.24LetPub ·
Impact factor (publisher) 2025
3.3Publisher website ·
CiteScore 2026-06
5.5LetPub ·
CiteScore (publisher) 2025
5.5Publisher website ·
SJR 2026-06
1.1LetPub ·
SNIP 2026-06
0.72LetPub ·
h-index
178LetPub ·
h-index
261OpenAlex ·
i10-index
6,481OpenAlex ·
2-year mean citedness
2.18OpenAlex ·
Self-citation rate
15.2%LetPub ·
Share of gold OA articles
38.66%LetPub ·

Volume

Articles per year
167LetPub ·
Articles per year (publisher) 2025
168Publisher website ·
Downloads per year (publisher) 2025
553,077Publisher website ·

Articles by year OpenAlex count · 10,254 in total · the current year is incomplete

YearArticlesOpen accessCitations
2026854621
2025203137477
202414395443
20232191602,500
2022186841,690
20212671404,483

Sources count differently and were observed at different times, so each source's own value is kept; "publisher" marks figures from the journal's website.

Review & acceptance

Review time and acceptance

Review time from article dates manuscript dates registered with Crossref · to

143 daysMedian, submission to acceptance · P25–P75 102 days – 214 days

Acceptance to online
median 14 days (97 articles)
Submission to online
median 161 days
Sample
97 articles with submission and acceptance dates (298 in the window); the latest was accepted on

Only articles that were accepted and published are counted, not the time spent on rejected manuscripts, so this usually runs longer than a publisher's "time to first decision".

Other sources

Average review time (community reports)
3–6 weeksLetPub ·
Average acceptance (community reports)
Fairly easyLetPub ·
Acceptance rate (publisher) 2025
26%Publisher website ·
Submission to first decision 2025
8 daysPublisher website ·
Submission to acceptance 2025
124 daysPublisher website ·
Acceptance to publication 2025
14 daysPublisher website ·
Peer review
Single anonymous peer review, Open peer reviewPublisher website

Community reports come from authors' own submissions (confidence 0.5) and are not a promise from the journal; for publisher figures, the journal's own definitions apply.

Fees & open access

APC and open-access policy

Hybrid open accessLetPub

A subscription journal in which authors can pay to publish their article open access.

SourceAPCFee waiverLicenseObserved
OpenAlexUSD 4,550 / EUR 3,810 / GBP 3,070——
Publisher websiteYes, amount not published——

A hybrid journal charges the APC only when the author chooses open access; publishing under the subscription model is usually free.

The journal's website is authoritative for fees; sources were observed at different times and each keeps its own value, without averaging.

Submission

Article types and submission policies (journal website)

What to prepare1 items from the author guidelines
Cover letter
Optional
Publisher website · model-extracted, each line checked against the text

Excerpts are quoted from the journal's website; "model summary" lines are written by Workers AI and checked against the text. The journal's website is authoritative.

Profile

Publication details and official links

Publisher
Wiley-Liss Inc.
Country or region
UNITED STATES
Language
English
Frequency
Semimonthly
Founded
1986
ISSN
0887-3585
Electronic ISSN
1097-0134
Latest issue on the website
Volume 94, Issue 10 (October 2026)
Official links

FAQ

Frequently asked questions about Proteins Structure Function and Bioinformatics

What CAS zone is Proteins Structure Function and Bioinformatics in?

In the 2025 upgraded edition of the CAS Journal Ranking, Proteins Structure Function and Bioinformatics is in Zone 4 of Biology, and in Zone 4 of the minor category Biochemistry & Molecular Biology / Biophysics. In the 2026 Xinrui edition it is in Zone 3 of Biology. Zones from different editions, and from major and minor categories, are not interchangeable.

What is the impact factor of Proteins Structure Function and Bioinformatics?

The latest impact factor listed by LetPub is 3.24; CiteScore 5.5, h-index 261.

How long does peer review take at Proteins Structure Function and Bioinformatics?

Based on the dates recorded on 97 articles published between October 2024 and October 2026 (the last 24 months), the median time from submission to acceptance is 143 days (interquartile range 102–214 days); authors report an average review time of 3–6 weeks; the community-reported acceptance is “Fairly easy”; the journal's website gives an acceptance rate of 26% (2025). Article statistics cover accepted papers only, publisher figures follow the journal's own definitions, and community reports come from authors' own submissions; none is a promise from the journal.

Where are the editorial board members of Proteins Structure Function and Bioinformatics based?

Of the 44 board members whose country the journal's board page names, 4 (about 9%) are in mainland China; the countries named most often are United States (28), Mainland China (4) and Germany (3). Counted from the institutions listed on the board page; for reference only.

Which databases index Proteins Structure Function and Bioinformatics?

According to LetPub and DOAJ records, Proteins Structure Function and Bioinformatics is indexed in SCIE and Scopus. The journal's website also lists MEDLINE, PubMed, INSPEC, Embase, CAS, CAB Abstracts, DBLP and Current Contents; that list has not been checked against each database.

Is Proteins Structure Function and Bioinformatics open access, and what is the APC?

Proteins Structure Function and Bioinformatics is a hybrid journal. For open-access publication: APC about USD 4,550.

Sources and updates

The facts on this page come from LetPub, Publisher website, OpenAlex; every figure is tagged with its source and the date it was observed, and conflicting values are kept per source. LetPub source page: view ↗ (archived 2026-08-26). Last updated: .