Journal profile · Mathematics-Applied Mathematics
npj Systems Biology and Applications
ISSN 2056-7189 · Springer Nature · ENGLAND · Founded 2015
npj Systems Biology and Applications: CAS Zone 2 · Biology (2025 upgraded edition); impact factor 4.42; fully open access; APC about USD 3,490; median 164 days to acceptance (103 articles, last 24 months); 157 articles in 2025; indexed in SCIE and Scopus.
Scope
Aims, scope and focus
npj Systems Biology and Applications is published by Springer Nature and is in Zone 2 of Biology in the CAS Journal Ranking (2025 upgraded edition). By OpenAlex counts of its recent articles, its largest topics are Gene Regulatory Network Analysis, Bioinformatics and Genomic Networks and Microbial Metabolic Engineering and Bioproduction, together about 40.8% of its articles. Its main subfields are Molecular Biology. (generated from OpenAlex topic counts and CAS ranking data)
A fully open access, multi- and interdisciplinary journal, npj Systems Biology and Applications is dedicated to publishing the highest quality papers on systems biology.
From the journal's Aims & Scope
Research area (LetPub): Mathematics-Applied Mathematics
Main research topics OpenAlex counts of recent articles; shares are approximate
- Gene Regulatory Network AnalysisBiochemistry, Genetics and Molecular Biology15.9%
- Bioinformatics and Genomic NetworksBiochemistry, Genetics and Molecular Biology14.8%
- Microbial Metabolic Engineering and BioproductionBiochemistry, Genetics and Molecular Biology10.1%
- Single-cell and spatial transcriptomicsBiochemistry, Genetics and Molecular Biology9%
- Computational Drug Discovery MethodsComputer Science5.2%
- Mathematical Biology Tumor GrowthMathematics4.4%
- Cell Image Analysis TechniquesBiochemistry, Genetics and Molecular Biology3.8%
- Gene expression and cancer classificationBiochemistry, Genetics and Molecular Biology3.7%
Rankings & indexing
CAS ranking and database indexing
CAS Journal Ranking
CAS Journal Ranking, upgraded edition (March 2025)Biology Zone 2
| Level | Category | Zone |
|---|---|---|
| Major | Biology | Zone 2 |
| Minor | Mathematical & Computational Biology | Zone 2 |
Top journal: noReview journal: no
CAS Xinrui Journal Ranking (March 2026)Biology Zone 2
| Level | Category | Zone |
|---|---|---|
| Major | Biology | Zone 2 |
| Minor | Mathematical & Computational Biology | Zone 1 |
Top journal: noReview journal: not marked
CAS Journal Ranking, previous upgraded edition (December 2023)Biology Zone 2
| Level | Category | Zone |
|---|---|---|
| Major | Biology | Zone 2 |
| Minor | Mathematical & Computational Biology | Zone 2 |
Top journal: noReview journal: no
Database indexing
SCIEScopusDOAJLetPub
International journal early-warning lists: not listed in any editionLetPub
Indexing the journal's website claims
Web of ScienceMEDLINEPubMedCASPublisher website
Other: Google Scholar, ProQuest, Dimensions, CNKI, Baidu, Naver, OCLC, Portico, CLOCKSS, BIOSIS, Biological Abstracts, CNPIEC, Chinese Academy of Medical Science (CAMS), Japanese Science and Technology Agency (JST), Meta, OCLC WorldCat Discovery Service, Ovid Discovery, SCImago, TD Net Discovery Service, Wanfang, eLibrary.ru
As the journal's website lists them, not checked against each database; for Web of Science editions the records above apply.
Editions, and major and minor categories, are shown separately and never merged into one zone; check which edition your institution uses before you submit or report.
Metrics
Impact metrics and publication volume
Impact
- Impact factor
- 4.42LetPub ·
- Impact factor (publisher) 2025
- 4.4Publisher website ·
- 5-year impact factor (publisher) 2025
- 4.2Publisher website ·
- CiteScore 2026-06
- 4.7LetPub ·
- SJR 2026-06
- 1.31LetPub ·
- SNIP 2026-06
- 0.89LetPub ·
- h-index
- 58OpenAlex ·
- i10-index
- 344OpenAlex ·
- 2-year mean citedness
- 4.79OpenAlex ·
- Self-citation rate
- 2.3%LetPub ·
- Share of gold OA articles
- 100%LetPub ·
Volume
- Articles per year
- 151LetPub ·
- Downloads per year (publisher) 2025
- 1,563,808Publisher website ·
Articles by year OpenAlex count · 859 in total · the current year is incomplete
| Year | Articles | Open access | Citations |
|---|---|---|---|
| 2026 | 195 | 195 | 82 |
| 2025 | 157 | 157 | 793 |
| 2024 | 151 | 151 | 1,535 |
| 2023 | 64 | 64 | 1,178 |
| 2022 | 50 | 50 | 845 |
| 2021 | 49 | 49 | 1,401 |
Sources count differently and were observed at different times, so each source's own value is kept; "publisher" marks figures from the journal's website.
Review & acceptance
Review time and acceptance
Review time from article dates manuscript dates registered with Crossref · to
164 daysMedian, submission to acceptance · P25–P75 132 days – 219 days
- Acceptance to online
- median 19 days (103 articles)
- Submission to online
- median 185 days
- Sample
- 103 articles with submission and acceptance dates (392 in the window); the latest was accepted on
Only articles that were accepted and published are counted, not the time spent on rejected manuscripts, so this usually runs longer than a publisher's "time to first decision".
Other sources
- Average review time (community reports)
- about 8 weeksLetPub ·
- Submission to publication (journal-reported)
- about 8 weeksDOAJ ·
- Peer review
- Single anonymous peer reviewDOAJ
Community reports come from authors' own submissions (confidence 0.5) and are not a promise from the journal; for publisher figures, the journal's own definitions apply.
Fees & open access
APC and open-access policy
Fully open accessDOAJ
Every article is open access; authors usually pay an article processing charge (APC).
| Source | APC | Fee waiver | License | Observed |
|---|---|---|---|---|
| DOAJ | EUR 2,990 / USD 3,490 / GBP 2,690 | Yes | CC BY, CC BY-NC-ND | |
| OpenAlex | USD 3,490 / EUR 2,990 / GBP 2,690 | — | — | |
| LetPub | GBP 2,490 / USD 3,290 / EUR 2,790 | Yes | — |
The journal's website is authoritative for fees; sources were observed at different times and each keeps its own value, without averaging.
Submission
Article types and submission policies (journal website)
Policy excerpts from the journal's websitePublication ethics, Open access
- Publication ethics
Member of and subscribes to the principles of the Committee on Publication Ethics (COPE). Model summary
This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.
Source ↗Publisher website ·- Open access Open Access
Fully open access journal. Model summary
npj Systems Biology and Applications is a fully open access journal. More on Creative Commons Attribution licenses and the benefits of publishing open access can be found in this section.
Source ↗Publisher website ·
Excerpts are quoted from the journal's website; "model summary" lines are written by Workers AI and checked against the text. The journal's website is authoritative.
Profile
Publication details and official links
- Publisher
- Springer Nature
- Country or region
- ENGLAND
- Language
- English
- Founded
- 2015
- ISSN
- 2056-7189
- Official links
- Journal homepage ↗LetPub
- Submission system ↗Publisher website
- Author guidelines ↗LetPub
- Aims & Scope ↗LetPub
- Special issues ↗Publisher website
- APC information ↗DOAJ
- Fee waivers ↗DOAJ
- Open access statement ↗DOAJ
- License & copyright ↗DOAJ
- Peer review process ↗LetPub
- Editorial board ↗LetPub
- Plagiarism policy ↗DOAJ
FAQ
Frequently asked questions about npj Systems Biology and Applications
What CAS zone is npj Systems Biology and Applications in?
In the 2025 upgraded edition of the CAS Journal Ranking, npj Systems Biology and Applications is in Zone 2 of Biology, and in Zone 2 of the minor category Mathematical & Computational Biology. In the 2026 Xinrui edition it is in Zone 2 of Biology. Zones from different editions, and from major and minor categories, are not interchangeable.
What is the impact factor of npj Systems Biology and Applications?
The latest impact factor listed by LetPub is 4.42; CiteScore 4.7, h-index 58.
How long does peer review take at npj Systems Biology and Applications?
Based on the dates recorded on 103 articles published between October 2024 and October 2026 (the last 24 months), the median time from submission to acceptance is 164 days (interquartile range 132–219 days); authors report an average review time of about 8 weeks. Article statistics cover accepted papers only, publisher figures follow the journal's own definitions, and community reports come from authors' own submissions; none is a promise from the journal.
Which databases index npj Systems Biology and Applications?
According to LetPub and DOAJ records, npj Systems Biology and Applications is indexed in SCIE, Scopus and DOAJ. The journal's website also lists Web of Science, MEDLINE, PubMed and CAS; that list has not been checked against each database.
Is npj Systems Biology and Applications open access, and what is the APC?
npj Systems Biology and Applications is a fully open-access journal. APC about USD 3,490.
Sources and updates
The facts on this page come from LetPub, OpenAlex, DOAJ, Publisher website; every figure is tagged with its source and the date it was observed, and conflicting values are kept per source. LetPub source page: view ↗ (archived 2026-08-25). Last updated: .