Journal profile · Toxicology
Chemico-Biological Interactions
ISSN 0009-2797 · eISSN 1872-7786 · Elsevier Ireland Ltd · NETHERLANDS · Semimonthly · Founded 1969
Chemico-Biological Interactions: CAS Zone 2 · Medicine (2025 upgraded edition); impact factor 5.22; hybrid open access; APC about USD 3,540; median 94 days to acceptance (116 articles, last 24 months); community-reported acceptance: about 75%; 404 articles in 2025; indexed in SCIE and Scopus.
Scope
Aims, scope and focus
Chemico-Biological Interactions is published by Elsevier Ireland Ltd and is in Zone 2 of Medicine in the CAS Journal Ranking (2025 upgraded edition). By OpenAlex counts of its recent articles, its largest topics are Carcinogens and Genotoxicity Assessment, Pharmacogenetics and Drug Metabolism and Cholinesterase and Neurodegenerative Diseases, together about 23.3% of its articles. (generated from OpenAlex topic counts and CAS ranking data)
A journal of molecular, cellular and biochemical toxicologyChemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.CBI discourages papers that are descriptive in nature and that do not address toxicological mechanisms (e.g., reports of toxicological effects following chemical exposure in absence of mechanistic experiments). CBI also discourages papers reporting on toxicological effects from materials, such as plant extracts or herbal medicines, that have not been chemically characterized.
From the journal's Aims & Scope
Research area (LetPub): Toxicology
Editor-in-chief Daniel R. DietrichPublisher website
Editorial board by country: 6 in mainland China (about 9%); most named United States 34, Mainland China 6, Germany 6, Sweden 3, United Kingdom 2 (66 members with a country) Editorial board ↗Publisher website ·
Main research topics OpenAlex counts of recent articles; shares are approximate
- Carcinogens and Genotoxicity AssessmentBiochemistry, Genetics and Molecular Biology9.7%
- Pharmacogenetics and Drug MetabolismPharmacology, Toxicology and Pharmaceutics7.8%
- Cholinesterase and Neurodegenerative DiseasesMedicine5.8%
- Pesticide Exposure and ToxicityAgricultural and Biological Sciences5.6%
- Genomics, phytochemicals, and oxidative stressBiochemistry, Genetics and Molecular Biology5.3%
- Drug Transport and Resistance MechanismsMedicine5%
- Diverse Scientific and Economic StudiesEconomics, Econometrics and Finance5%
- Human auditory perception and evaluationEngineering4.9%
Rankings & indexing
CAS ranking and database indexing
CAS Journal Ranking
CAS Journal Ranking, upgraded edition (March 2025)Medicine Zone 2
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 2 |
| Minor | Toxicology | Zone 1 |
| Minor | Biochemistry & Molecular Biology | Zone 2 |
| Minor | Pharmacology & Pharmacy | Zone 2 |
Top journal: noReview journal: no
CAS Xinrui Journal Ranking (March 2026)Medicine Zone 2
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 2 |
| Minor | Biochemistry & Molecular Biology | Zone 2 |
| Minor | Pharmacology & Pharmacy | Zone 2 |
| Minor | Toxicology | Zone 1 |
Top journal: noReview journal: not marked
CAS Journal Ranking, previous upgraded edition (December 2023)Medicine Zone 2
| Level | Category | Zone |
|---|---|---|
| Major | Medicine | Zone 2 |
| Minor | Toxicology | Zone 1 |
| Minor | Biochemistry & Molecular Biology | Zone 2 |
| Minor | Pharmacology & Pharmacy | Zone 2 |
Top journal: noReview journal: no
Database indexing
SCIEScopusLetPub
International journal early-warning lists: not listed in any editionLetPub
Editions, and major and minor categories, are shown separately and never merged into one zone; check which edition your institution uses before you submit or report.
Metrics
Impact metrics and publication volume
Impact
- Impact factor
- 5.22LetPub ·
- Impact factor (publisher)
- 5.2Publisher website ·
- CiteScore 2026-06
- 10.3LetPub ·
- CiteScore (publisher)
- 10.3Publisher website ·
- SJR 2026-06
- 1.23LetPub ·
- SNIP 2026-06
- 1.2LetPub ·
- h-index
- 108LetPub ·
- h-index
- 188OpenAlex ·
- i10-index
- 7,174OpenAlex ·
- 2-year mean citedness
- 5.11OpenAlex ·
- Self-citation rate
- 1.9%LetPub ·
- Share of gold OA articles
- 14.65%LetPub ·
Volume
- Articles per year
- 369LetPub ·
Articles by year OpenAlex count · 11,418 in total · the current year is incomplete
| Year | Articles | Open access | Citations |
|---|---|---|---|
| 2026 | 354 | 65 | 164 |
| 2025 | 404 | 109 | 1,945 |
| 2024 | 380 | 108 | 3,711 |
| 2023 | 404 | 96 | 6,014 |
| 2022 | 410 | 83 | 9,652 |
| 2021 | 305 | 75 | 7,736 |
Sources count differently and were observed at different times, so each source's own value is kept; "publisher" marks figures from the journal's website.
Review & acceptance
Review time and acceptance
Review time from article dates manuscript dates registered with PubMed · to
94 daysMedian, submission to acceptance · P25–P75 64 days – 130 days
- Acceptance to online
- median 2 days (116 articles)
- Submission to online
- median 97 days
- Sample
- 116 articles with submission and acceptance dates (842 in the window); the latest was accepted on
Only articles that were accepted and published are counted, not the time spent on rejected manuscripts, so this usually runs longer than a publisher's "time to first decision".
Other sources
- Average review time (community reports)
- about 1 monthLetPub ·
- Average acceptance (community reports)
- 75%LetPub ·
- Submission to first decision
- 7 daysPublisher website ·
- First decision after review
- 37 daysPublisher website ·
- Submission to acceptance
- 96 daysPublisher website ·
- Acceptance to publication
- 2 daysPublisher website ·
- Peer review
- Single anonymous peer reviewPublisher website
Community reports come from authors' own submissions (confidence 0.5) and are not a promise from the journal; for publisher figures, the journal's own definitions apply.
Fees & open access
APC and open-access policy
Hybrid open accessLetPub
A subscription journal in which authors can pay to publish their article open access.
| Source | APC | Fee waiver | License | Observed |
|---|---|---|---|---|
| OpenAlex | USD 3,540 / EUR 3,310 / GBP 2,830 / JPY 439,070 | — | — | |
| Publisher website | USD 3,580 | — | — |
A hybrid journal charges the APC only when the author chooses open access; publishing under the subscription model is usually free.
Other charges and waivers (author guidelines)
- Submission fee
- No submission fee
The journal's website is authoritative for fees; sources were observed at different times and each keeps its own value, without averaging.
Submission
Article types and submission policies (journal website)
What to prepare5 items from the author guidelines
- Abstract
- ≤ 250 words
- Keywords
- 1–7
- Reference style
- Numbered, in order of citation
- Templates
- LaTeX and Word
- Highlights
- Required
Article types accepted3
- letter to the editorLetters to the EditorLength not stated
- letters to the editorChemico-Biological Interactions will publish, Papers reporting results of original mechanistic research; Review articles; Letters to the Editor; Announcements a…Length not stated
- review articleChemico-Biological Interactions will publish, Papers reporting results of original mechanistic research; Review articles; Letters to the Editor; Announcements a…Length not stated
Policy excerpts from the journal's websiteAI use, Authorship, Conflicts of interest, Data availability, License & copyright, Open access, Peer review, Preprints
- AI use Declaration of generative AI use
Authors must declare the use of generative AI tools in the manuscript preparation process upon submission of the paper.Generative AI and AI-assisted technologies (“AI tools”) have been rapidly adopted in research and scholarly publishing, offering significant benefits while requiring clear standards for responsible and transparent use.Authors preparing a manuscript for this journal may use AI tool…
Source ↗Publisher website ·- Authorship Group authorship
Group authorship refers to the attribution of an article to a defined and named group of authors whose members have contributed to the work. Examples include research consortia, clinical trial groups, collaborative networks, task forces or working groups, expert panels or consensus groups, and participatory research groups. Group authorship must be declared on the title page at submission. When av…
Source ↗Publisher website ·- Conflicts of interest Declaration of competing interests
All authors must disclose any financial and personal relationships with other people or organizations that could inappropriately influence or bias their work. Examples of potential competing interests include:EmploymentConsultanciesStock ownershipHonorariaPaid expert testimonyPatent applications or registrationsGrants or any other fundingAffiliation with the journal as an Editor or Advisory Board …
Source ↗Publisher website ·- Data availability
Data statement required at submission Model summary
To foster transparency, you are required to state the availability of any data at submission.
Source ↗Publisher website ·- License & copyright License options
Authors will be offered open access user license options which will determine how you, and third parties, can reuse your open access article. We advise that you review these options and any funding body license requirements before selecting a license option.
Source ↗Publisher website ·- Open access Open access
We refer you to our open access information page to learn about open access options for this journal.
Source ↗Publisher website ·- Peer review Peer review
Single anonymized review process Model summary
This journal follows a single anonymized review process. Your submission will initially be assessed by our editors. If your submission is deemed suitable, it will typically be sent to be reviewed by a minimum of two reviewers for an independent expert assessment of the scientific quality. The decision as to whether your article is accepted or rejected for publication will be made by our editors.Re…
Source ↗Publisher website ·- Preprints Preprints
Preprint sharing allowed Model summary
Preprint sharingAuthors may share preprints in line with Elsevier's article sharing policy. Sharing preprints, such as on a preprint server, will not count as prior publication.We advise you to read our policy on multiple, redundant or concurrent publication.
Source ↗Publisher website ·
Excerpts are quoted from the journal's website; "model summary" lines are written by Workers AI and checked against the text. The journal's website is authoritative.
Profile
Publication details and official links
- Publisher
- Elsevier Ireland Ltd
- Country or region
- NETHERLANDS
- Language
- English
- Frequency
- Semimonthly
- Founded
- 1969
- ISSN
- 0009-2797
- Electronic ISSN
- 1872-7786
- Official links
- Journal homepage ↗OpenAlex
- Submission system ↗Publisher website
- Special issues ↗Publisher website
FAQ
Frequently asked questions about Chemico-Biological Interactions
What CAS zone is Chemico-Biological Interactions in?
In the 2025 upgraded edition of the CAS Journal Ranking, Chemico-Biological Interactions is in Zone 2 of Medicine, and in Zone 1 of the minor category Toxicology / Biochemistry & Molecular Biology / Pharmacology & Pharmacy. In the 2026 Xinrui edition it is in Zone 2 of Medicine. Zones from different editions, and from major and minor categories, are not interchangeable.
What is the impact factor of Chemico-Biological Interactions?
The latest impact factor listed by LetPub is 5.22; CiteScore 10.3, h-index 188.
How long does peer review take at Chemico-Biological Interactions?
Based on the dates recorded on 116 articles published between October 2024 and October 2026 (the last 24 months), the median time from submission to acceptance is 94 days (interquartile range 64–130 days); authors report an average review time of about 1 month; the community-reported acceptance is “about 75%”. Article statistics cover accepted papers only, publisher figures follow the journal's own definitions, and community reports come from authors' own submissions; none is a promise from the journal.
What are the manuscript requirements of Chemico-Biological Interactions?
According to the journal's author guidelines: Abstract: ≤ 250 words; Keywords: 1–7; Reference style: Numbered, in order of citation; Templates: LaTeX and Word; Highlights: Required. A model extracted these from the author guidelines and each was checked against the text; check the latest version on the journal's website before submitting.
Where are the editorial board members of Chemico-Biological Interactions based?
Of the 66 board members whose country the journal's board page names, 6 (about 9%) are in mainland China; the countries named most often are United States (34), Mainland China (6) and Germany (6). Counted from the institutions listed on the board page; for reference only.
Which databases index Chemico-Biological Interactions?
According to LetPub and DOAJ records, Chemico-Biological Interactions is indexed in SCIE and Scopus.
Is Chemico-Biological Interactions open access, and what is the APC?
Chemico-Biological Interactions is a hybrid journal. For open-access publication: APC about USD 3,540.
Sources and updates
The facts on this page come from LetPub, Publisher website, OpenAlex; every figure is tagged with its source and the date it was observed, and conflicting values are kept per source. LetPub source page: view ↗ (archived 2026-08-25). Last updated: .