Molecular Therapy Nucleic Acids

Molecular Therapy Nucleic Acids 由 Cell Press 出版，属中科院医学大类（2025 升级版2区，Top 期刊）。按 OpenAlex 近年发文统计，该刊主要发表 RNA Interference and Gene Delivery、MicroRNA in disease regulation、Cancer-related molecular mechanisms research 等主题的论文，这 3 个主题约占 34.6%，主导子领域为 Molecular Biology。（根据 OpenAlex 主题统计与中科院分区数据生成）

Molecular Therapy Nucleic Acids is an international, open-access journal publishing top-quality basic, translational, and clinical research in the broad fields of nucleic-acid-based therapeutics to treat and/or correct genetic and acquired disease. As an official journal of the American Society of Gene & Cell Therapy, Molecular Therapy Nucleic Acids builds upon the success of Molecular Therapy in publishing important peer-reviewed research, cutting-edge reviews, and commentaries targeted to advances in gene- and oligonucleotide-based therapies. Molecular Therapy Nucleic Acids's 2024 impact factor is 6.1Subject areas include but are not limited to: development of therapeutics based on nucleic acids and their derivatives, vector development and design for the delivery of RNA-based therapeutics, applications of gene-modifying agents including triplex-forming oligonucleotides and enzymes such as Zn finger nucleases, pre-clinical target validation, nucleic acid immunity, safety/efficacy studies, and clinical trials.To accommodate the rapid growth of Molecular Therapy Nucleic Acids, starting in 2022, articles will be submitted and published in one of following subsections covering key topics.Subsections include:BioinformaticsAINGSmathematical modelingphylogenetic oligo arraysClinical applicationsOriginal research featuring clinical or translational studiesCase series or first-in-human trials with significant implicationsEarly-phase clinical trial results (phase I/II)Advanced preclinical research with strong potential for clinical translationDelivery strategieschemistryligandslipid nanoparticleslocalized delivery applicationspolymeric nanoparticlessystemic deliverytargeted deliveryviral vectorsNon-coding RNAscircRNAslncRNAsmiRNAssiRNAsregulatory guidelinesNucleic acid immunityNucleic acid sensing: mechanisms of innate immune recognition and signaling by DNA and RNA sensors, including TLRs, RIG I–like receptors, and cGAS.Pathway regulation: molecular control of activation, amplification, and resolution of nucleic acid–triggered innate immune signaling.Cell-autonomous antiviral immunity: antiviral restriction factors and nucleases involved in cell-autonomous antiviral immunityNucleic acid homeostasis: innate immune sensing of nucleic acid homeostasis and nucleic acid metabolismAltered self nucleic acids: alterations of self nucleic acids (oxidation, displacement, modification, cleavage, damage) that activate or inhibit nucleic acid immunityEvolutionary antiviral systems: restriction-modification enzymes, CRISPR-Cas, cyclic-oligonucleotide-based antiphage signaling system, and RNAi in antiviral immunityEngineered nucleic acids: design, development, and enzymatic or chemical synthesis of nucleic acids that modulate innate immune receptor activityNucleic acid therapeutics: strategies to prevent innate immune sensing in nucleic acid therapeutics (e.g., ASOs, small interfering RNAs (siRNAs), mRNAs, microRNAs (miRNAs), viral vectors)Therapeutic immune activation: therapeutic use of nucleic acids to induce innate immune activation (e.g., in cancer or infectious disease)Disease and aging: nucleic acid immunity and disease, including interferonopathies, lupus, neurodegeneration, and other aging-related diseases.Oligonucleotides: diagnostics and biosensorsaptamer-based biosensorsmolecular beaconsnanostructured biosensorsradiolabeled oligonucleotidesrolling circle amplification-based biosensorsOligonucleotides: therapies and applicationsclinical studiesCMCdevelopmentdiscoverypreclinical assessmentregulatory RNAsRNA/DNA editingADARCRISPRHDRNHEJTALENZFN

摘自期刊官网 Aims & Scope

研究方向（LetPub）：MEDICINE, RESEARCH & EXPERIMENTAL

中科院期刊分区表

数据库收录

SCIEScopusDOAJLetPub

预警 / 风险提示：2026年03月发布的新锐学术版：不在预警名单中 2025年03月发布的2025版：不在预警名单中 2024年02月发布的2024版：不在预警名单中 2023年01月发布的2023版：不在预警名单中 2021年12月发布的2021版：预警等级：高 2020年12月发布的2020版：不在预警名单中LetPub

不同版本、大类与小类分别展示，不将不同评价口径合并为一个分区值；投稿与考核前请确认所在机构采用的版本。

影响力指标

影响因子（出版商公布） 2024

6.1出版商官网 · 2026-10-01

CiteScore 2026-06

10.8LetPub · 2026-09-13

CiteScore（出版商公布）

10.8出版商官网 · 2026-10-01

SJR 2026-06

2.07LetPub · 2026-09-13

SNIP 2026-06

1.1LetPub · 2026-09-13

h-index

43LetPub · 2026-09-13

h-index

131OpenAlex · 2026-10-01

i10-index

2,255OpenAlex · 2026-10-01

两年平均被引

5.2OpenAlex · 2026-10-01

自引率

4.6%LetPub · 2026-09-13

Gold OA 文章占比

100%LetPub · 2026-09-13

发文规模

年文章数

280LetPub · 2026-09-13

不同来源的统计口径与观测时间不同，页面保留各来源原值；“出版商公布”为期刊官网自述数据。

其他来源

平均审稿速度（社区反馈）

20 WeeksLetPub · 2026-09-13

投稿到接收

138 天出版商官网 · 2026-10-01

投稿到发表（期刊自报）

约 23 周DOAJ · 2026-10-11

评审方式

单盲同行评审DOAJ

社区反馈来自投稿者样本，置信度 0.5，不代表期刊承诺；“出版商公布”的时间节点定义以官网为准。

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费用以期刊官网为准；不同来源的观测时间可能不同，页面保留各来源原值，不做平均。

摘录来自期刊官网页面，仅保留原文片段；“模型摘要”由 Workers AI 生成并经原文校验，以官网为准。

出版商

Cell Press

出版国家或地区

UNITED STATES

出版语言

English

ISSN

2162-2531

学会 / 主办单位

American Society of …

官方链接

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• Aims & Scope ↗DOAJ
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• APC 费用说明 ↗DOAJ
• 费用减免政策 ↗DOAJ
• 开放获取声明 ↗DOAJ
• 许可与版权 ↗DOAJ
• 评审流程 ↗LetPub
• 编委会 ↗DOAJ